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However, the fact that QUIN concentrations are about 5000- to 15,000-fold lower than cerebral L-glu concentrations makes it highly unlikely that modulation of NMDA receptor signaling by QUIN plays a significant role

With the exception of HC rats, all were subjected to eight different chronic unpredictable mild stimuli for 14 weeks, including 8 weeks of depression model development and a 6-week treatment period

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