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Glutathionylation of Keap1 is responsible for the release of Nrf2 during times of oxidative stress, allowing for translocation of Nrf2 to the nucleus where it positively regulates expression of genes containing antioxidant-responsive elements (AREs) (Kensler et al., 2007

Rodden LN, Chutake YK, Gilliam K, Lam C, Soragni E, Hauser L, Gilliam M, Wiley G, Anderson MP, Gottesfeld JM, Lynch DR, Bidichandani SI

Notes: Muscarine and nicotine are naturally occurring alkaloids that were used to pharmacologically identify and characterize receptor subtypes before the endogenous neurotransmitter (acetylcholine or Vagusstoff) was identified

However, always consult your doctor or dermatologist before starting, particularly if you have any pre-existing health conditions or are taking other medications