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Additionally, spermidine preserves key initiators of autophagosome formation by devitalizing caspase-3-mediated beclin1 cleavage [96]

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Moreover, while repeated injections of STING agonists induce strong innate and adaptive immune responses, they inevitably upregulate immune checkpoint molecules, creating a negative feedback loop that may confer adaptive resistance to STING agonist-induced immune responses [248]