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Defective respiration and one-carbon metabolism contribute to impaired naive t cell activation in aged mice

Key Research Areas Selective GHS-R1a pharmacology Ipamorelin is a standard reference compound in ghrelin receptor research, offering clean, selective GHS-R1a agonism without the receptor cross-reactivity seen in GHRP-2 and GHRP-6 GH pulse amplitude studies Studied for its capacity to increase GH pulse amplitude without altering pulse frequency a mechanistically important distinction in GH secretion pattern research Cortisol/ACTH independence A key research utility of Ipamorelin is that GH secretagogue effects can be studied in isolation from the HPA axis activation that complicates interpretation of GHRP-2 and GHRP-6 studies Synergistic GHRH/GHRP protocols Most frequently studied in combination with CJC-1295 No DAC

*Correspondence: Yulan Li, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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