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United Kingdom Legal framework: Peptides not FDA-approved fall under Medicines Act Legal to possess for personal use Illegal to supply/sell without license Prescription peptides (like semaglutide) require prescription Research peptides: Gray area similar to US Personal possession generally tolerated Selling requires licensing Canada Legal status: Health Canada regulates peptides Similar to US - prescription peptides legal with prescription Research peptides gray area Possession for personal use generally tolerated Australia Stricter regulations: Therapeutic Goods Administration (TGA) regulates Many peptides require prescription Importing peptides can be seized at customs Stricter enforcement than US/UK Prescription required for: Most peptides including those available as research chemicals elsewhere

Even when incubating at 95C for 10 minutes, some enzymatic activity remains

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doi: 10.1073/pnas.1405158111