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Although not considered a change in structure to the BBB per se, endothelial cells can increase leukocyte adhesion molecule expression leading to increased leukocyte extravasation into the brain parenchyma under pathological conditions [58, 59]

This positioning applies to research and implies no statement about safety or efficacy in humans

Collaborators GBDPsD (2018) Global, regional, and national burden of Parkinsons disease, 19902016: a systematic analysis for the Global Burden of Disease Study 2016