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doi: 10.1073/pnas.2009201117 27 KraftVANBezjianCTPfeifferSRingelstetterLMullerCZandkarimiFet al

They're not really a function of the dose being too high or your serum B12 level being too high

Abbreviations ACLF: Acute-On-Chronic Liver Failure ALF: Acute liver failure ALLO: Allopregnanolone BBB: Bloodbrain barrier BCAAs: Branched-chain amino acids BDL: Bile-duct ligated cGMP: Cyclic guanosine monophosphate CFF: Critical Flicker Frequency CHE: Covert hepatic encephalopathy CHESS: Clinical Hepatic Encephalopathy Staging Scale CLF: Chronic liver failure CRT: Continuous Reaction Time CSF: Cerebrospinal fluid EEG: Electroencephalogram FMT: Fecal microbiota transplantation GPB: Glycerol phenylbutyrate HE: Hepatic encephalopathy HESA: Hepatic Encephalopathy Scoring Algorithm ICT: Inhibitory Control Test ISHEN: Society for Hepatic Encephalopathy and Nitrogen Metabolism LOLA: l-Ornithine and L-aspartate MARS: Molecular Adsorbent Recirculating System mHE: Minimal hepatic encephalopathy NKA: Na + K + ATPase OHE: Overt hepatic encephalopathy OP: Ornithine phenylacetate PEG: Polyethylene glycol PHES: Psychometric Hepatic Encephalopathy Score RBANS: Repeatable battery for the assessment of neuropsychological status RCTs: Randomized controlled trials SIRS: Systemic inflammatory response syndrome THDOC: Tetradehydrodeoxycorticosterone References American Association for the Study of Liver D, European Association for the Study of the L

Oral exposure of dimethylarsinic acid, a main metabolite of inorganic arsenics, in mice leads to an increase in 8-Oxo-2-deoxyguanosine level, specifically in the target organs for arsenic carcinogenesis