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However, comprehensive clinical studies including the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and European First-Episode Schizophrenia Trial (EUFEST), revealed no clear advantages of atypical over typical drugs in terms of efficacy ( Figure 3 Antipsychotic-Induced EPS Clinical Symptoms Major EPS symptoms associated with antipsychotic treatment of BPSD include Parkinsonian symptoms, akathisia, and dystonia