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However, contradicting the benefit of NAC and nitroxides in treating Atm-null mice, increasing oxidative stress by co-deleting either SOD1 or SOD2 (superoxide dismutases), or using different antioxidants (EUK-189 (Mn(III) salen) or -Tocopherol (vitamin E)), had no impact on survival or tumorigenesis 24,25 , while overexpression of SOD1 negatively impacted Atm-null mouse phenotypes (see Table S1 for summary)