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Two practical consequences fall out of this mechanism, and both explain the shape of the protocol below

6b), and was noticeably absent in circular puncta that mostly represent organelles such as peroxisomes and mitochondria (Fig

Significant accumulation of lipid peroxides is observed in brain regions enriched with A oligomers and in 4-HNE-positive areas of AD patients, indicating direct involvement of A in the ferroptosis pathway (118)

Interestingly, prominent hydrogen bonds, formed between the generated amine groups of Metro with the carbonyl oxygen of C P and the amine group of Metro-P3 with carbonyl oxygen of Ser54, provide a rationale for the inhibition of HpTpx red solely by the reduced ligands, explaining why the nitro-prodrugs cannot act as inhibitors of HpTpx