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rather, within the multivalent complex, each module contributes, but no single element is indispensable, allowing the assembly to remain operative even when one component is compromised

Further, direct binding of heavy metals, particularly mercury and arsenic, to seleno-cysteine, the selenium complex found in the active catalytic site of glutathione peroxidase and thioredoxin-reductase, will reduce synthesis of these enzymes as well as inactivate them by forming a tight complex with selenium in the catalytic site [5][6]

Regardless, this MAY not be a thing where you empirically reduce your starting dose of warfarin, but you should at least consider it combination with other sensitivity factors

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