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A 2026 review in Anais Brasileiros de Dermatologia confirmed these reactions are typically local, appear within 24 to 48 hours of injection, and resolve in 3 to 5 days without stopping treatment

10.1038/s41419-023-05855-4 7 HondaY.KessokuT.SumidaY.KobayashiT.KatoT.OgawaY.et al (2017)

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These results indicate that sulfasalazine induces tubulointerstitial injury and that inhibition of the formation of TLS by sulfasalazine is not mediated by the attenuation of kidney damage