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Confocal laser scanning microscope (CLSM) was used to observe the process of iLYTAC(or IGF2-Z) transporting proteins to lysosomes for degradation

PLoS One 7(7):40972 Wijesekara N, Dai FF, Hardy AB, Giglou PR, Bhattacharjee A, Koshkin V, Chimienti F, Gaisano HY, Rutter GA, Wheeler MB (2010) Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion