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Nicorandil and carvedilol mitigates motor deficits in experimental autoimmune encephalomyelitis-induced multiple sclerosis: Role of TLR4/TRAF6/MAPK/NF-B signalling cascade

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The microglia are central nervous system immune cells that produce: Inflammation Pain sensitivity Fatigue Sleeplessness Mood disorders Cognitive problems When microglia are chronically activated, as they are with fibromyalgia and other pain disorders, it results in neurotoxicity and then an extensive cascade of symptoms that are associated with all these conditions