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GPT2 downregulation in the GBM mesenchymal subtype correlated to upregulation of genes involved in GSH synthesis Once Glu is synthesized it can be converted to KG, an intermediate of the TCA cycle, by glutamate dehydrogenase (GLUD1) and glutamate transaminases, as glutamate oxaloacetate transaminases (GOT1cytosolic and GOT2mitochondrial) and glutamate pyruvate transaminases (GPT1cytosolic and GPT2mitochondrial), which transfer amino groups from oxaloacetate or from pyruvate to generate KG and aspartate or alanine, respectively [17]

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Detoxification and protection : Antioxidant injections help neutralize free radicals and support liver health

IGFBPs can also act to guide IGF-1 to specific tissues, or even to inhibit or potentiate IGF-1 actions by acting as an independent substrate for the IGF-1R and/or other specific membrane, intracellular or nuclear receptors [7]