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The most dramatic increase is in the perimenopause population: as of February 2026, 1 in 20 women aged 4554 has an active estrogen-based HRT prescription, a 184% increase across the study period

see NHS guidance and Xenical/Alli SmPCs), and injectable GLP-1 receptor agonists such as semaglutide (Wegovy) and liraglutide (Saxenda)

Practices monitoring nutritional complications, such as the B12 and iron deficiencies common after gastrectomy, can also lean on metabolic health workflows to keep recurring lab and supplementation follow-ups on track

Greater endurance enhanced ability to maintain effort over time due to more efficient oxygen utilization