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doi: 10.1016/j.nut.2004.06.026 26 KoopmanG.ReutelingspergerC

However, the increasing variability of climate, characterized by prolonged droughts, unpredictable rainfall, and extreme temperatures, intensifies the frequency and severity of abiotic and biotic stresses, posing significant threats to plant survival and productivity [7]

Additionally, synthesis of prodrugs like -glutamyl 3,4-dihydroxyphenylalanine (L-DOPA) has been reported to have increased half-life due to resistance to cleavage by general serum proteases (Hara et al., 1992

It may therefore interfere with methylation- dependent metabolism and indicate poor flow through the methionine cycle