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This distinction between the DAC and no-DAC forms is central and is covered in depth in the dedicated CJC-1295 DAC vs no-DAC dosage protocol reference

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Consequently, Arg143 interposes between disulfide bond residues Cys57 and Cys146 and greatly increases solvent accessibility of the SOD1 Cubinding site, [47] ensuring the amenability of the active site to receive Cu whilst simultaneously preventing premature disulfide bond formation

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