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The metE protein was formulated in two distinct adjuvants, AddaS03 and AS01, capable of inducing robust immune responses with a high safety profile ( MTB and lungs and spleens were collected for bacterial enumeration at the end of the study ( Figure 5A )

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Pharmaceuticals 16 (11), 1588

framework substitutions are identified by methods well known in the art, e.g., by modeling of the interactions of the CDR and framework residues to identify framework residues important for antigen binding and sequence comparison to identify unusual framework residues at particular positions