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We hypothesized that by defining more precisely the eicosanoid profile in arthritis patients, we might identify not only novel diagnostic or prognostic biomarkers for disease activity, but also a better understanding of the pathogenesis of rheumatoid arthritis, psoriatic arthritis, and osteoarthritis

Concurrently, alterations in the gut microbiota impact uremic toxin metabolism, as certain butyrate-producing bacteria themselves contribute to indole sulfate production, which in turn exacerbates renal injury ( Table 1 ) [84, 89]

& Schadt, K

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