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Reelin has been linked to depression in preclinical models of depression: A decline in reelin expression in the hippocampal subgranular zone is associated with the emergence of depression-like behavior, and heterozygous reeler mice (HRM) with 50% of the normal levels of reelin are highly susceptible to the depressogenic effects of stress hormones (Lussier et al., 2011, 2013)

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