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Intra-articular injections of 0.3 mL of NSO (5 weeks) in 57 months old male New Zealand white rabbits prevented the degeneration of cartilage at the prior stages of osteoarthritis [267]

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More significantly, these perturbed compositions represented stratification with disease severity, plasma concentrations of inflammatory factors, and blood markers of tissue damage (Yeoh et al., 2021)