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ROS and intracellular iron accumulation are important processes that trigger the mitogen-activated protein kinase (MAPK) pathway, decrease intracellular glutathione (GSH) depletion, and limit cystine absorption

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Interestingly, in normal cells, this process leads to a milder outcome, resulting in cellular senescence [43]

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Macropinocytosis: mechanism and targeted therapy in cancers

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