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Amphetamine has been used as an animal model of mania since 1978, and it is twice as likely to trigger psychosis than methylphenidate (Moran LV et al, N Engl J Med 2019;380(12):11281138)

10.1007/s40200-022-01053-9 118 ZhangB.ChenX.RuF.GanY.LiB.XiaW.et al (2021)

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Some studies in rodents have added KYNA at massive doses (well over 100 mg/kg, getting into the millimolar range in serum/plasma), seemingly without ill effects (indeed sometimes with protective effects)