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Mounjaro also acts on a second hormone pathway, and early trials suggest it may produce even greater weight loss than semaglutide alone

Gandhi NS, Tekade RK, Chougule MB

Abbreviations ARE: Antioxidant response element ASN: Asparagine CCK-8: Cell counting kit-8 CETSA: Cellular thermal shift assay CHX: Cycloheximide CNS: Central nervous system DA: Dopamine DAergic: Dopaminergic DOPAC: 3,4-Dihydroxy phenylacetic acid ELISA: Enzyme-linked immunosorbent assay EPS: Epalrestat FBS: Fetal bovine serum GCLC: Glutamate-cysteine ligase catalytic subunit GSH: Glutathione HO-1: Heme oxygenase-1 HPLC-ECD: High-performance liquid chromatography with electrochemical detection HVA: Homovanillic acid KEAP1: Kelch-like ECH-associating protein 1 LCMS/MS: Liquid chromatography-tandem mass spectrometry LDH: Lactate dehydrogenase MAO-B: Monoamine oxidase B MDA: Malondialdehyde m: Mitochondrial membrane potential MPP + : 1-Methyl-4-phenylpyridillium ion MPTP: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine N2a: Neuro-2a mouse neuroblastoma NQO1: NAD(P)H: quinone oxidoreductase-1 Nrf2: Nuclear factor erythroid 2-related factor OFT: Open field test PD: Parkinsons disease ROS: Reactive oxygen species SER: Serine siRNA: Small interfering RNA SN: Substantia nigra SPR: Surface plasmon resonance TEM: Transmission electron microscopy References Berg D, Postuma RB, Bloem B, Chan P, Dubois B, Gasser T, Goetz CG, Halliday GM, Hardy J, Lang AE, et al