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androgenic imbalances, which account for the majority of weight gain seen by women with PCOS, are among the most essential hormonal imbalances

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In the other hand, autoAb with relevant agonist properties are those directed against the PDGFR with induction of the ROS-ERK1/2-Ha-Ras loop and increased collagen gene transcription in human fibroblasts in vitro and in vivo in a humanized mouse model of skin fibrosis [163, 164]