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Merola et al

Following a 1-month baseline period, during which all cats consumed a 34% protein diet, the animals were fed the designated protein diets for 2 months

Simultaneously, studies using molecular biology detection and pharmacological intervention confirmed that heat stress triggers cPLA2 activation and increases the level of its metabolite arachidonic acid to participate in lipid peroxidation in the mouse heatstroke model, further promoting the occurrence of ferroptosis, thereby aggravating the progression of ALI after heat stress [48]

In the following years, it has been proven that after the intraperitoneal administration of thymopentin (15 g per 100 g of body weight) to healthy mice, the activation of cytokines (IL-1-, IL-2, IL-6, IL-10 and IFN-), nitric oxide and heat shock proteins (Hsp70 and Hsp90) occurs in peritoneal macrophages and splenic lymphocytes (Lunin and Novoselova 2010