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doi: 10.3892/ijo.2015.3084 83 WeinbergRA

While the general architecture of the cerebral cortex is conserved across these species, there are discrepancies in cell-type diversity and transcriptional regulation [168, 169], including divergence in gene expression in homologous cell types [170]

Cancers with highly upregulated mTOR activity are frequently challenging to standard therapies, and reducing mTOR activity significantly impairs cancer growth by breaking their metabolic flexibility