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A few flashbacks to their friendship, more moments showing their history, or even just a little extra tension to build the chemistry

Secondly, the effects of most OS modulators exhibit significant context dependency and even contradictory properties

This suggests that the pathological processes and tissue damage established over years of CFTR dysfunction may not be entirely reversible by the current levels of CFTR correction achieved, or that the restoration of CFTR function is insufficient to fully extinguish these self-perpetuating cycles of inflammation and oxidative damage