doi: 10.1038/s41597-023-02365-y 87 AvrilTVauleonEHamlatASaikaliSEtcheverryADelmasCet al
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Joint and Recovery Benefits Cartilage regeneration: Early data suggests possible joint-protective properties, making it a potential therapeutic candidate for osteoarthritis and cartilage repair Advantages Over Other Fat-Loss Therapies No IGF-1 elevation: Avoids risks of acromegaly or unwanted tissue growth
Herbal agents including AST IV, 96 Puerarin, 97 Baicalin, 98 Apigenin 99 and Salidroside 100 counter this resistance by modulating apoptotic protein expression (eg, reducing Bcl-2/Bax ratio, activating Caspase-3) through pathways such as the mitochondrial pathway (Salidroside via A2aR), AMPK1/p53/Bax/Bcl-2/caspase cascade, HIF-1/Kv1.5 signaling, or PI3K/Akt inhibition, thereby inducing PASMC apoptosis and attenuating medial thickening
