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Mol Brain 5:35 [DOI] [PMC free article] [PubMed] [Google Scholar] 82.Oosterveen T, Garo P, Moles-Garcia E, Soleilhavoup C, Travaglio M, Sheraz S, Peltrini R, Patrick K, Labas V, Combes-Soia L et al (2021) Pluripotent stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinsons disease

Furthermore, NETs can activate the complement system, exacerbate endothelial damage and promote platelet activation

This direct method ensures rapid absorption and immediate antioxidant effects, reducing melanin production, detoxifying the liver, and combating oxidative stress

While O 2 released into the mitochondrial matrix is directly converted by SOD2 into the less reactive H 2 O 2 , O 2 released by the complex III into the mitochondrial intermembrane space can be exported via voltage-dependent anion channels (VDAC) into the cytosol followed by a SOD1-mediated conversion into H 2 O 2 [6, 7]