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In addition to stating that estimands should be used, the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines also emphasize the importance of considering intercurrent events when defining the scientific question of interest and underline key principles for handling missing data [3]

Patients report a significantly better tolerance compared to traditional options, making it suitable for a broader demographic, including those with pre-existing health concerns

Tirzepatide provides powerful weight loss and blood sugar control but requires medical supervision and may cause more side effects.

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