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In cattle with mastitis weak acid antibiotics are typically administered by intramammary infusion, whereas weak bases are administered parenterally

10.1080/17425255.2021.1940952 Expert Opin

Paracetamol is a weak inhibitor of PG synthesis of COX-1 and COX-2 in broken cell systems, but, by contrast, therapeutic concentrations of paracetamol inhibit PG synthesis in intact cells in vitro when the levels of the substrate arachidonic acid are low (less than about 5 mol/L)