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Endocrinology 146 , 851860 (2005)

The most common ROS include hydrogen peroxide (H 2 O 2 ), superoxide anion radical (O 2 ), and hydroxyl radical (HO) [37, 38]

Research indicates preferential accumulation in actively dividing cells and tissues with high metabolic activity, including dermal fibroblasts, keratinocytes, and endothelial cells