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These findings suggest that modulation of VEGF-related signaling pathways contributes to the anticancer effects of PYC ( PYC also exhibits indirect anticancer effects through its antioxidant properties and protection against DNA damage

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Recent studies have confirmed that ferroptosis is associated with resistance to cancer treatment, and dysregulation of ferroptosis often leads to drug resistance and treatment failure

Therefore, it is necessary to further research the potential mechanisms by which the gut microbiome leads to intestinal barrier disruption and how to effectively prevent subsequent mucosal immune dysregulation