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One possible mechanism to explain this change on BMI and fat mass is the effect of selenium, particularly the selenoproteins glutathione peroxidase and selenoproteins P, on the regulation of enzymes of the insulin signaling cascade, the expression of lipogenic enzymes and in carbohydrate metabolism in the liver

It stimulates the release of growth hormone (GH) and also triggers the emission of insulin-like growth factor 1 (IGF-1)

Methods/design Study type This study takes the form a pragmatic, randomised, multicentre, non-inferiority clinical trial undertaken in the primary healthcare setting, with a duration of one year

Understanding these reactions helps distinguish expected responses from those requiring medical attention