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Sci Transl Med (2019) 11(500):eaav5467

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Moreover, Confounding factors including genetics, diet, and infections further complicate the interpretation of research findings ( Given that genetic factors contribute approximately 65% of individual Vitamin D 3 level variance, precision medicine approaches become increasingly important ( VDR gene polymorphisms, treatment responders can be precisely identified across different disease phenotypes, genetic backgrounds, and baseline states, thereby overcoming the limitations of conventional one-size-fits-all supplementation approaches, maximizing therapeutic benefits while minimizing resource waste

In these situations, I recommend B12 shots as first-line therapy over oral forms