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Mechanistically, GLPs exert renoprotective effects by suppressing the PI3K/Akt/mTOR signaling cascade, promoting autophagicevidenced by increased Beclin-1 expression and LC3-II/LC3-I ratio, along with decreased p62 accumulationwhile simultaneously attenuating apoptotic activity (reducing caspase-3 and caspase-9 levels) and dampening pro-inflammatory responses (lowering IL-6, IL-1, and TNF-)

For instance, activation of NRF2 promotes ROS clearance in drug-resistant liver cancer cell lines [31]

doi: 10.1016/j.drudis.2008.11.006 14 BrancatoVOliveiraJMCorreloVMReisRLKunduSC

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