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Disrupting cholesterol/sphingolipids of lipid rafts reduces the stability of surface AMPA receptors and leads to the loss of both inhibitory and excitatory synapses and dendritic spines, while also increasing the internalization of unstimulated receptors

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Rodriguez-Iruretagoiena A, Trebolazabala J, Martinez-Arkarazo I, de Diego A, Madariaga JM