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These findings indicated that CUR/miR155@DssD-Hb NPs could stimulate ROS generation mediated by CUR as a ROS initiator in tumor cells, potentially hastening nanoparticle disintegration and CUR release, thereby establishing a positive feedback loop to bolster antitumor efficacy

Basal lipid peroxidation in substantia nigra is increased in Parkinsons disease

The enhanced susceptibility of CF AECs to ferroptosis is consistent with the published literature suggesting that iron homeostasis is disrupted in the CF lung [20, 21]

Different from other classical cell death programs such as necrosis and apoptosis, ferroptosis involving iron-catalyzed lipid peroxidation is characterized by Fe 2+ accumulation and mitochondria alterations