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It not only enhances mitochondrial function in skeletal muscle and other organs, increases mitochondrial content, boosts the transcriptional activity of related proteins, and reduces the production of ROS, but also improves metabolic flexibilityall of these effects lay a solid physiological foundation for the core goal of cognitive prehabilitation, which is to preserve cognitive health

As a case in point, Li and co-workers loaded dihydroartemisinin (DHA) into iron-based MOFs to design a peroxidase-like nanoreactor (termed DHA@MIL-101 NR) for synergistic CDT-ferroptotic therapy (Figure 5C) (Yang et al., 2022a)

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Zhong et al., 2006), glucose metabolism (Totary-Jain et al., 2005), lipoproteins (Srivastava et al., 1992), hypoxia (Fieber et al., 2006