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Over 70 countries, including countries of North America, South America, West, East, and Southern Africa, Central and Southeast Asia, Australia, and New Zealand, have implemented mandatory folic acid fortification of foods until 2022, starting with the United States of America in 1998 680,689,690,691,692

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This high-load operational state places the mitochondria of tumor cells on the verge of damage and stress, making the cells highly dependent on mitochondrial quality control (MQC) mechanisms, such as mitophagy, to clear dysfunctional organelles [43]

Pasero, P