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Intranasally administered labeled siRNA distributed along the olfactory pathway to the brain and was detected within the olfactory epithelium, the olfactory nerve as well as in the glomerular and mitral cell layer of the olfactory bulb [31]

In addition, overexpression of MLYCD can inhibit the expression of ferroptosis-negative genes, such as SCD1 , and upregulate ferroptosis-positive genes, including PTGS2 , ALB and AQP3