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Its research profile makes it especially relevant for studies focused on body-composition pathway models, energy balance, metabolic flexibility, adipose tissue biology, and NAD+-adjacent cellular signaling

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However, no data are available on MUC5B + -derived organoids cultured without hormones or under conditions supplemented with E2 + PGR agonists + cAMP, thus limiting the ability to draw conclusions on the phenotype and hormone-responsiveness of the MUC5B + epithelial cells [16]