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In OA, these cells can trigger the release of cartilage substances such as IL-1 and TNF- , which generate MMPs and inhibit the production of collagen and proteoglycan, leading to low-grade synovitis (73)

Joint pain, especially from conditions like arthritis, can make it difficult for dogs to find a comfortable sleeping position

Through our scientific and clinical network, we aim to ensure that a translational science approach to understanding GPX4 biology will lead to new therapeutics for patients suffering from this disease