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Costello James P

As a proof of concept, local Slc38a3 silencing using vivo morpholino technique resulted in astrocytic swelling and increased volume of the brain region subjected to silencing (Hamdani et al., 2021)

Of note, most of these side effects were later attributed to the concomitant inhibition of mTORC2, which occurs following chronic mTORC1 inhibition and as a result of rapamycin binding to mTOR, thus affecting mTORC2 formation (Lamming et al., 2012)

These deficits correlate with structural MRI findings of 30% gray matter loss in hippocampal subfields, particularly the CA1 and dentate gyrus, regions critical for memory consolidation and emotional regulation