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34,37 The requirement for local metabolic activation of NNK in the mouse lung has been elegantly demonstrated by experiments using mice in which cytochrome P450-reductase, the requisite co-factor for cytochrome P450-catalyzed metabolic activation of NNK, has been knocked out in the lung, 38 and a polymorphism in Cyp 2A5 decreased NNK-induced DNA adduct formation and lung tumorigenesis, as seen in parallel epidemiologic studies of lung cancer

To estimate adjusted odds ratios (AORs) and 95% confidence intervals (CIs) for hyperuricemia by smoking status, duration, intensity, and cumulative dose in study population A, multiple logistic regression analyses were conducted

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The following timeline depicts the overall progression of this process, including the estimated times when certain symptoms and reactions are likely to arise