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In nucleic acids, 8-oxoG lesions, abasic sites and single- or double-strand breaks ariseoften near metal centers bound to DNAtriggering repair programs like base-excision repair (BER) and PARP-dependent pathways that, when over-activated, consume NAD/ATP and can precipitate bioenergetic failure and broader metabolic collapse (Banda et al

Another study found that prominin-2 protects breast cancer cells from ferroptotic cell death by promoting the formation of ferritin-containing multivesicular bodies and exosomes that transport ferritin out of the cell ( Lung Cancer Several studies revealed that iron is closely associated with the development of lung cancer, and the disruption of iron homeostasis makes cells more sensitive to ferroptosis (Kuang and Wang, 2019)

Therapeutic strategies should integrate pharmacological interventions (e.g., anti-inflammatory and psychiatric medications), oral hygiene management (e.g., regular scaling and enhanced oral cleansing), psychological interventions, and microbiota modulation (e.g., probiotic administration) to create a comprehensive treatment model (Qian J

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