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This Notch intracellular domain then translocates to the nucleus, where it forms a complex with CSL and Mastermind-like, regulating target gene expression and influencing critical cellular processes such as inflammation, apoptosis, and proliferation, which are crucial to the pathogenesis of PH as demonstrated by several clinical and preclinical studies (Fig

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When ordinary cells are stimulated by ROS, the antioxidant system activates rapidly, reducing damage to cell structures by removing or neutralizing ROS

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