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It plays a central role in neutralizing free radicals, supporting liver detoxification, and maintaining immune function

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Collectively, these findings question the notion that mitochondria are the primary source of ROS production in contracting skeletal muscle and future studies will be required to fully define the role that mitochondria play in exercise-induced production of ROS in muscle

For example, ER stress activates DNA damage inducible transcript 3 (DDIT3, also known as CHOP)- and mitogen-activated protein kinase 8 (MAPK8, also known as JNK)-dependent apoptosis pathways, whereas heat shock protein family A member 5 (HSPA5, also known as BIP) SSG at Cys420/441 modulates ATPase activity and protein folding, paradoxically suppressing apoptosis 49